Description

Sivelestat Sodium is a potent and selective inhibitor of human neutrophil elastase (HNE). This compound is of significant interest in pharmaceutical research and development, particularly for its potential therapeutic applications in managing inflammatory conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of treatments for acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and other neutrophil-mediated pathologies. Sivelestat Sodium CAS NO 201677-61-4 represents a critical tool for investigating protease inhibition and inflammatory pathways.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of neutrophil elastase inhibitors.
• Biochemical Research: Used as a selective tool compound in in vitro and ex vivo studies to elucidate the role of human neutrophil elastase in inflammatory cascades.
• Preclinical Studies: Employed in animal models to investigate efficacy and pharmacokinetics for conditions like acute lung injury (ALI) and pancreatitis.
• Analytical Standard: Serves as a high-purity standard for method development and quality control (HPLC, LC-MS) in analytical laboratories.
• Inflammation Pathway Analysis: Facilitates target validation and screening within drug discovery programs focused on protease targets.

Basic Information

Product Name	Sivelestat Sodium
CAS No.	201677-61-4
Molecular Formula	C20H19N4NaO6S
Molecular Weight	458.44 g/mol
Synonyms	Sivelestat Sodium Hydrate; ONO-5046 Sodium; N-[2-[4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino]benzoyl]aminoacetic Acid Sodium Salt; Elaspol; Sivelestat Sodium Salt; (S)-Sivelestat Sodium; Sivelestat (sodium salt); AE-3763
EINECS	Contact for details

Quality Control

Our Sivelestat Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which include results from HPLC, NMR, and mass spectrometry. Specifications are aligned with research-grade and pharmaceutical intermediate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.