Description

L-Alanine-n-T-Boc (2-13C) is a stable isotope-labeled derivative of the amino acid alanine, specifically carbon-13 labeled at the C-2 position and protected with a tert-butoxycarbonyl (Boc) group on the nitrogen. This compound is essential for advanced research requiring precise metabolic and pharmacokinetic tracing, offering unparalleled accuracy in mass spectrometry and NMR studies. It is a critical building block for pharmaceutical, biotechnology, and academic researchers developing novel peptide-based therapeutics and conducting detailed metabolic pathway analysis.

Application

• Isotope-Labeled Pharmaceutical Intermediates: Synthesis of carbon-13 labeled peptides and APIs for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Used as a tracer in in vitro and in vivo studies to elucidate biochemical pathways using NMR or LC-MS.
• Proteomics & Biomarker Research: Internal standard for the absolute quantification of proteins and peptides in complex biological matrices via mass spectrometry.
• Structural Biology & NMR Spectroscopy: Facilitates the structural elucidation of large biomolecules by providing specific sites for isotopic labeling.
• Preclinical & Clinical Research: Key reagent in the development and validation of bioanalytical methods for new chemical entities.

Basic Information

Product Name	L-Alanine-n-T-Boc (2-13C)
CAS No.	201612-65-9
Molecular Formula	C8H1513CNO4
Molecular Weight	~190.20 g/mol (for 13C isotopologue)
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino](2-13C)propanoic Acid; N-Boc-L-alanine-2-13C; N-(tert-Butoxycarbonyl)-L-alanine-2-13C; Boc-L-Ala-2-13C-OH; Boc-L-Alanine-2-13C; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, (2-13C)-; 2-13C-L-Alanine N-Boc derivative
EINECS	Contact for details

Quality Control

Every batch of L-Alanine-n-T-Boc (2-13C) is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We guarantee high chemical and isotopic purity, with specifications typically meeting or exceeding the requirements for research and pharmaceutical development. A detailed Certificate of Analysis (COA), including data for assay, isotopic enrichment, chiral purity, and impurity profile, is provided with each shipment to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.