Description

Fmoc-D-Pen(Trt)-Oh is a high-purity, protected amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled introduction of the non-proteinogenic amino acid D-penicillamine into peptide chains, enabling the research and development of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on peptide-based drug discovery, therapeutic agent development, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of custom peptides, particularly those requiring the incorporation of D-penicillamine.
• Pharmaceutical Research: Used in the development of peptide therapeutics, enzyme inhibitors, and receptor ligands where the thioether moiety of penicillamine is crucial for activity or structure.
• Bioconjugation & Labeling: Serves as a precursor for creating functionalized peptides for conjugation with drugs, dyes, or other biomolecules.
• Chemical Biology Studies: Employed to synthesize peptide probes for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Material Science: Can be used to create peptide-based biomaterials and hydrogels with specific chemical functionalities.

Basic Information

Product Name	Fmoc-D-Pen(Trt)-Oh
CAS No.	201532-01-6
Molecular Formula	C41H37NO4S
Molecular Weight	639.80 g/mol
Synonyms	Fmoc-D-penicillamine(trityl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-dimethyl-D-cysteine (S-trityl); Fmoc-D-Pen(Trt)-OH; Fmoc-D-3,3-dimethylcysteine(S-trityl)-OH; N-α-Fmoc-S-trityl-D-penicillamine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3,3-dimethyl-3-(tritylsulfanyl)propanoic acid; Fmoc-D-Pen(Strt)-OH; Fmoc-D-Pen(Trt)
EINECS	Contact for details

Quality Control

Our Fmoc-D-Pen(Trt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and our quality systems support compliance with relevant standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.