Description

Fmoc-Pen(Acm)-Oh is a protected amino acid derivative, specifically an Fmoc-protected L-penicillamine with an acetamidomethyl (Acm) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of penicillamine residues into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of peptides containing penicillamine.
• Pharmaceutical Research: Used in the development of novel peptide-based drugs, including enzyme inhibitors and receptor ligands.
• Bioconjugation: Serves as a precursor for creating peptide-protein conjugates or peptide-drug conjugates due to the reactive thiol group after deprotection.
• Chemical Biology: Employed in the study of protein folding, metal binding sites, and disulfide bridge formation in synthetic peptides.
• Material Science: Can be used to create functionalized surfaces or biomaterials with specific thiol-reactive properties.

Basic Information

Product Name	Fmoc-Pen(Acm)-Oh
CAS No.	201531-76-2
Molecular Formula	C₂₃H₂₆N₂O₅S
Molecular Weight	442.53 g/mol
Synonyms	Fmoc-L-penicillamine(Acm)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-[(acetamidomethyl)thio]-D-valine; Fmoc-Pen(Acm)-OH; Fmoc-S-acetamidomethyl-L-penicillamine; Nα-Fmoc-S-acetamidomethyl-L-penicillamine; Fmoc-S-Acm-L-penicillamine; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(acetamidomethyl)sulfanyl]-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Pen(Acm)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research and cGMP-grade synthesis requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.