Description

Fmoc-3,3-Diphenyl-L-Alanine CAS NO 201484-50-6 is a high-purity, non-proteinogenic amino acid derivative extensively used as a critical building block in solid-phase peptide synthesis (SPPS). Its unique diphenyl side chain provides significant steric bulk and hydrophobicity, making it invaluable for introducing specific conformational constraints and enhancing the stability of synthetic peptides. This compound is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise control over peptide structure and function.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research: Used in the development of novel therapeutic peptides, including hormone analogs, enzyme inhibitors, and receptor ligands.
• Bioconjugation & Probe Design: Incorporates hydrophobic, bulky motifs into fluorescent tags, affinity probes, or drug-linker constructs.
• Material Science: Serves as a monomer for creating specialized peptide-based polymers and biomaterials with tailored properties.
• Academic & Industrial R&D: Fundamental reagent for studying peptide structure-activity relationships (SAR) and folding.

Basic Information

Product Name	Fmoc-3,3-Diphenyl-L-Alanine
CAS No.	201484-50-6
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-Diphenylalanine; Fmoc-3,3-Diphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,3-diphenyl-L-alanine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3,3-diphenylpropanoic acid; Fmoc-Dpa-OH; Fmoc-L-3,3-Diphenylalanine; N-Fmoc-3,3-diphenyl-L-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-3,3-Diphenyl-L-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.