Description

(4S)-4-Methyl-L-Proline Hcl is a high-purity, non-proteinogenic amino acid derivative used as a critical chiral building block in advanced organic synthesis. This compound is essential for introducing conformational constraints and modifying the pharmacokinetic properties of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide-based drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for constrained peptides.
• Peptidomimetics Design: Used to synthesize peptide analogs with enhanced metabolic stability, bioavailability, and receptor selectivity.
• Asymmetric Synthesis: Serves as a versatile precursor or catalyst ligand in stereoselective chemical transformations.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and proteomics research.
• Ligand Development: Useful for creating novel chelating agents and ligands for metal catalysis or molecular recognition.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies and compound libraries in medicinal chemistry.

Basic Information

Product Name	(4S)-4-Methyl-L-Proline Hydrochloride
CAS No.	201481-62-1
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	(4S)-4-Methyl-L-proline hydrochloride; L-4-Methylproline hydrochloride; (2S,4S)-4-Methylpyrrolidine-2-carboxylic acid hydrochloride; 4-Methyl-L-proline HCl; (S)-4-Methylproline hydrochloride; 4(S)-Methyl-L-proline hydrochloride; 4-Methyl-(S)-proline hydrochloride; 201481-62-1
EINECS	Contact for details

Quality Control

Our (4S)-4-Methyl-L-Proline Hcl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and optical rotation measurement, to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.