Description

Boc-N-Me-Phe(4-NO2)-OH·DCHA is a protected amino acid derivative, specifically the tert-butyloxycarbonyl (Boc) derivative of N-methyl-4-nitrophenylalanine, isolated as its dicyclohexylamine (DCHA) salt. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase peptide coupling. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive peptides, and advanced materials chemistry.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase peptide synthesis (SPPS) and solution-phase methods for the controlled incorporation of N-methylated, nitro-substituted phenylalanine residues.
• Protease Inhibitor Development: Acts as a precursor in the design and synthesis of inhibitors targeting specific proteolytic enzymes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the construction of modified peptide probes for biochemical assays.
• Material Science: Utilized in the synthesis of specialized polymers and dendrimers with peptide-based backbones for advanced material applications.

Basic Information

Product Name	Boc-N-Me-Phe(4-NO2)-OH·DCHA
CAS No.	201420-91-9
Molecular Formula	C₂₇H₄₃N₃O₆
Molecular Weight	505.65 g/mol
Synonyms	Boc-N-methyl-4-nitrophenylalanine dicyclohexylamine salt; (2S)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-(4-nitrophenyl)propanoic acid compound with dicyclohexylamine; Boc-N-Me-Phe(p-NO2)-OH·DCHA; N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-4-nitro-L-phenylalanine dicyclohexylamine salt; tert-Butyl N-methyl-N-[(2S)-1-oxo-3-(4-nitrophenyl)-1-[(dicyclohexylamino)oxy]propan-2-yl]carbamate; Boc-N-Me-4-NO2-Phe-OH·DCHA; Nα-Boc-Nα-methyl-4-nitro-L-phenylalanine DCHA salt
EINECS	Contact for details

Quality Control

Our Boc-N-Me-Phe(4-NO2)-OH·DCHA is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.