Description

(3As,8Ar)-2-(2-Diphenylphosphinophenyl)-3A,8A-Dihydroindane[1,2-D]Oxazole CAS NO 201409-47-4 is a specialized, chiral phosphine-oxazoline (PHOX) ligand, a critical class of organocatalysts in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer intermediates in pharmaceutical and fine chemical manufacturing. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical synthesis, and advanced material science who require precise stereochemical control.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for rhodium, iridium, or ruthenium complexes in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral active pharmaceutical ingredients (APIs) with high optical purity, critical for drug efficacy and safety.
• Asymmetric C-C Bond Formation: Used in Heck reactions, allylic alkylations, and other cross-coupling reactions to construct complex chiral molecules.
• Agrochemical Production: Facilitates the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Research: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in organic chemistry.
• Fine Chemical Manufacturing: Applied in the synthesis of specialty chemicals, flavors, and fragrances where chirality impacts product performance.

Basic Information

Item	Details
Product Name	(3As,8Ar)-2-(2-Diphenylphosphinophenyl)-3A,8A-Dihydroindane[1,2-D]Oxazole
CAS No.	201409-47-4
Molecular Formula	C29H24NOP
Molecular Weight	433.48 g/mol
Synonyms	(S)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-(1-methylethyl)oxazole; (S)-2-(2-Diphenylphosphinophenyl)-4-isopropyl-4,5-dihydrooxazole; (S)-PHOX Ligand; Josiphos-type ligand derivative; Chiral PHOX ligand; P,N-Ligand; Asymmetric hydrogenation ligand; (3aS,8aR)-2-(2-Diphenylphosphinophenyl)-3a,8a-dihydroindeno[1,2-d]oxazole
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess (ee) meet stringent requirements. We provide comprehensive Certificates of Analysis (COA) detailing results from HPLC, NMR, and chiral analysis. Our quality management system adheres to cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.