Description

Ac-p-Iodo-D-Phe-Oh is a high-purity, non-natural amino acid derivative featuring a para-iodinated phenylalanine backbone with an acetylated N-terminus and a free carboxylic acid. This compound serves as a critical chiral building block and intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of peptide-based therapeutics, radiopharmaceuticals, and targeted molecular probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide drugs and bioactive molecules.
• Radiopharmaceutical Precursor: Acts as a precursor for iodine-123 or iodine-131 labeled compounds used in diagnostic imaging and therapy.
• Peptide Research: Used in solid-phase and solution-phase peptide synthesis to incorporate iodinated aromatic amino acids.
• Proteomics & Biochemistry: Employed as a modified amino acid in the study of protein structure, function, and protein-protein interactions.
• Chemical Biology Tool: Utilized in the development of enzyme inhibitors, receptor ligands, and activity-based probes.
• Standards & Reference Material: Serves as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	Ac-p-Iodo-D-Phe-Oh
CAS No.	201351-59-9
Molecular Formula	C11H12INO3
Molecular Weight	333.12 g/mol
Synonyms	N-Acetyl-4-iodo-D-phenylalanine; Ac-4-I-D-Phe-OH; N-Acetyl-p-iodo-D-phenylalanine; (R)-2-Acetamido-3-(4-iodophenyl)propanoic acid; Ac-D-Phe(4-I)-OH; N-Acetyl-D-4-iodophenylalanine; p-Iodo-D-phenylalanine, N-acetyl-; Ac-p-I-D-Phe-OH
EINECS	Contact for details

Quality Control

Every batch of Ac-p-Iodo-D-Phe-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our standard quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and GMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.