Description

H-D-Thr(Bzl)-Nh2 Hcl is a protected derivative of the non-natural amino acid D-Threonine, specifically designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, stereochemically defined building blocks to create complex peptides with specific biological activities. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the controlled assembly of peptide chains, particularly where the D-threonine stereochemistry is required.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and targeted drug conjugates.
• Bioconjugation & Labeling: Serves as a specialized linker or handle in the site-specific modification of peptides and proteins for diagnostic or therapeutic purposes.
• Combinatorial Chemistry Libraries: Employed to introduce structural diversity and specific chiral centers into libraries for high-throughput screening in drug discovery.
• Biochemical Research: Used as a standard or reagent in studies investigating peptide structure-activity relationships, enzyme specificity, and molecular recognition.

Basic Information

Product Name	H-D-Thr(Bzl)-Nh2 Hcl
CAS No.	201275-09-4
Molecular Formula	C11H17ClN2O2
Molecular Weight	244.72 g/mol
Synonyms	D-Threonine, O-benzyl-, amide, hydrochloride; H-D-Thr(Bzl)-NH2·HCl; (2R,3S)-2-Amino-3-(benzyloxy)butanamide hydrochloride; D-Thr(Bzl)-NH2 HCl; D-O-Benzylthreoninamide hydrochloride; (2R,3S)-3-(Benzyloxy)-2-aminobutanamide hydrochloride; Fmoc-D-Thr(Bzl)-OH precursor; Protected D-Threonine amide HCl salt
EINECS	Contact for details

Quality Control

Our H-D-Thr(Bzl)-Nh2 Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under controlled environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry atmosphere to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.