Description

Bzl-Ser(Bzl)-Oh is a protected serine derivative, specifically O-benzyl-L-serine, where both the amino and carboxyl groups are benzylated. This compound is a crucial building block in the synthesis of complex peptides and pharmaceuticals, offering precise control over stereochemistry and reactivity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in advanced organic synthesis and peptide drug development.

Application

• Peptide Synthesis: Serves as a key protected amino acid intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic peptides and peptidomimetics.
• Bioconjugation: Acts as a linker or spacer molecule in the conjugation of peptides to other biomolecules or surfaces.
• Chemical Biology Research: Employed in the study of enzyme mechanisms and protein-protein interactions where modified serine residues are required.
• Protecting Group Chemistry: Demonstrates the application of benzyl (Bzl) groups for the protection of hydroxyl and carboxyl functionalities in multistep syntheses.
• Reference Standard: Used as a high-purity analytical standard for quality control in peptide manufacturing.

Basic Information

Product Name	Bzl-Ser(Bzl)-Oh
CAS No.	201209-83-8
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.34 g/mol
Synonyms	O-Benzyl-L-serine; N-Benzyloxycarbonyl-O-benzyl-L-serine; Z-Ser(Bzl)-OH; Cbz-Ser(Bzl)-OH; N-Carbobenzoxy-O-benzyl-L-serine; (2S)-2-[(Benzyloxy)carbonylamino]-3-(phenylmethoxy)propanoic acid; L-Serine, N-[(phenylmethoxy)carbonyl]-, O-(phenylmethyl) ester; Bzl-Ser(Bzl)-OH
EINECS	Contact for details

Quality Control

Our Bzl-Ser(Bzl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances, ensuring compliance with research and cGMP-grade standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.