Description

Fmoc-Orn(Fmoc)-Oh is a protected amino acid derivative, specifically Nα,Nδ-di-Fmoc-L-ornithine, which is a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its dual orthogonal protection strategy, where the Fmoc groups on both the α- and δ-amino groups of ornithine allow for selective deprotection and controlled peptide chain elongation. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing complex peptides, peptidomimetics, and bioconjugates that require the specific incorporation of a side-chain functionalized ornithine residue.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled incorporation of ornithine into peptide sequences using Fmoc-chemistry protocols.
• Pharmaceutical Research: Used in the development of therapeutic peptides, including antimicrobial peptides (AMPs) and hormone analogs, where ornithine's side-chain amine is crucial for activity or further modification.
• Bioconjugation and Linker Chemistry: The δ-amino group, once selectively deprotected, serves as a key attachment point for linking peptides to other molecules, dyes, or solid supports.
• Peptidomimetic Design: Employed in creating modified peptide structures with enhanced stability or bioavailability for drug discovery programs.
• Chemical Biology Probes: Useful for synthesizing labeled or tagged peptides used in studying protein-protein interactions and cellular processes.
• Custom Peptide Service Providers: A staple raw material for CROs and CDMOs offering bespoke peptide synthesis services to academic and industrial clients.

Basic Information

Product Name	Fmoc-Orn(Fmoc)-Oh
CAS No.	201046-59-5
Molecular Formula	C36H34N2O6
Molecular Weight	590.67 g/mol
Synonyms	Nα,Nδ-Bis(9-fluorenylmethoxycarbonyl)-L-ornithine; Di-Fmoc-L-ornithine; Fmoc-Orn(Fmoc)-OH; Nα-Fmoc-Nδ-Fmoc-L-ornithine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid; Fmoc-Orn(Fmoc); L-Ornithine, N2,N5-bis[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-Orn(Fmoc)-Oh is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.