Description

L(+)-Fmoc-Ornithine HCl is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the ornithine residue, enabling the research and development of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on novel therapeutic agents, diagnostic tools, and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the sequential assembly of peptides on resin.
• Bioconjugation and Linker Chemistry: The side-chain amine of ornithine, once deprotected, provides a unique handle for attaching labels, tags, or other molecules.
• Research into Polyamine Analogues: Used to synthesize and study modified polyamines for potential applications in oncology and cellular regulation.
• Development of Cell-Penetrating Peptides (CPPs): Ornithine-rich sequences are key components in designing peptides that facilitate cellular uptake.
• Enzyme Substrate and Inhibitor Design: Employed in creating specific substrates or inhibitors for enzymes like transglutaminases and ornithine decarboxylase.
• Production of Custom Peptide Libraries: Essential for combinatorial chemistry approaches to discover new bioactive compounds.

Basic Information

Item	Detail
Product Name	L(+)-Fmoc-Ornithine HCl
CAS No.	201046-57-3
Molecular Formula	C₂₀H₂₂N₂O₄ • HCl
Molecular Weight	382.86 g/mol
Synonyms	Fmoc-Orn(Boc)-OH • HCl; Nα-Fmoc-Nδ-Boc-L-ornithine hydrochloride; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((tert-butoxycarbonyl)amino)pentanoic acid hydrochloride; Fmoc-L-Orn(Boc)-OH • HCl; Nδ-Boc-Nα-Fmoc-L-ornithine hydrochloride; Fmoc-Ornithine(Boc)-OH hydrochloride; Boc-Orn(Fmoc)-OH • HCl; L-Ornithine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Every batch of L(+)-Fmoc-Ornithine HCl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for peptide synthesis. Our quality assurance protocol includes HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	+10.0° to +12.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.