Description

Fmoc-Nle-Osu CAS NO 201026-08-6 is a high-purity, activated ester derivative of the unnatural amino acid norleucine, protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled incorporation of norleucine into peptide chains. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and biotechnology who require precise and reliable amino acid derivatives for constructing complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the Fmoc-strategy of peptide synthesis, facilitating the coupling of norleucine residues.
• Pharmaceutical Research & Development: Used in the synthesis of therapeutic peptides, peptide hormones, and drug candidates where norleucine acts as a stable isostere for methionine or leucine.
• Bioconjugation and Protein Engineering: Employed to introduce norleucine tags or functional handles into proteins and biomolecules for labeling, cross-linking, or structural studies.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic Research: Fundamental tool in biochemistry and chemical biology laboratories for studying protein structure, function, and interactions.
• Production of Custom Peptides: Used by CROs and CDMOs for the reliable and scalable manufacture of custom peptides for clients.

Basic Information

Product Name	Fmoc-Nle-Osu
CAS No.	201026-08-6
Molecular Formula	C21H20N2O6
Molecular Weight	396.40 g/mol
Synonyms	Fmoc-Norleucine-OSu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-norleucine N-hydroxysuccinimide ester; Fmoc-L-norleucine-OSu; Fmoc-Nle-OSu; Nα-Fmoc-Nω-hydroxysuccinimidyl L-norleucinate; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)hexanoic acid 2,5-dioxopyrrolidin-1-yl ester; Fmoc-Nle-Osu ester; Fmoc-L-2-Aminohexanoic acid N-succinimidyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Nle-Osu is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.