Description

2-Bromo-4-Fluoro-1-(2,2,2-Trifluoroethoxy)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen and trifluoroethoxy substituents enable precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine and bromine atoms contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) and introducing the trifluoroethoxy moiety into target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of proprietary compounds and fine chemicals.

Basic Information

Product Name	2-Bromo-4-Fluoro-1-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	200956-26-9
Molecular Formula	C8H5BrF4O
Molecular Weight	273.03 g/mol
Synonyms	1-Bromo-2-Fluoro-4-(2,2,2-Trifluoroethoxy)Benzene; 2-Bromo-4-Fluorophenyl Trifluoroethyl Ether; 2-Bromo-1-Fluoro-4-(2,2,2-trifluoroethoxy)benzene; Benzene, 2-bromo-4-fluoro-1-(2,2,2-trifluoroethoxy)-; 4-Fluoro-2-bromo-1-(2,2,2-trifluoroethoxy)benzene; 2-Bromo-4-fluoro(2,2,2-trifluoroethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluoro-1-(2,2,2-Trifluoroethoxy)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and lot-to-lot consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.