Description

(S)-(+)-4,12-Bis(Diphenylphosphino)[2.2]Paracyclophane(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is a highly specialized, chiral organometallic complex that serves as a premier asymmetric hydrogenation catalyst. Its value lies in its unique, atropisomeric [2.2]paracyclophane backbone, which provides exceptional stereocontrol in the synthesis of enantiomerically pure compounds. This catalyst is essential for researchers and process chemists in the pharmaceutical and fine chemical industries seeking to develop efficient, stereoselective synthetic routes for active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Key in the production of enantiomerically pure building blocks for APIs, including β-amino acids and chiral amines.
• Fine Chemical Manufacturing: Enables high-precision, stereocontrolled reactions for the synthesis of specialty chemicals, flavors, and fragrances.
• Academic and Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Used to develop scalable, efficient, and selective manufacturing processes for chiral molecules.

Basic Information

Product Name	(S)-(+)-4,12-Bis(Diphenylphosphino)[2.2]Paracyclophane(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate
CAS No.	200808-73-7
Molecular Formula	C48H44BF4P2Rh
Molecular Weight	884.52 g/mol
Synonyms	(S)-[2.2]Paracyclophane-4,12-diylbis(diphenylphosphine)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (S)-4,12-Bis(diphenylphosphino)[2.2]paracyclophane(COD)rhodium(I) tetrafluoroborate; (S)-PhanePHOS(COD)RhBF4; (S)-[Rh(PhanePHOS)(COD)]BF4; (S)-Rh-PhanePHOS Catalyst; (S,S)-Rh(PhanePHOS)(nbd)BF4 (related complex); Chiral Rhodium(I)-PhanePHOS Complex
EINECS	Contact for details

Quality Control

Every batch of our (S)-(+)-4,12-Bis(Diphenylphosphino)[2.2]Paracyclophane(1,5-Cyclooctadiene)Rhodium(I) Tetrafluoroborate is synthesized and handled under inert atmosphere to preserve its catalytic activity and chiral integrity. We employ advanced analytical techniques, including NMR, HPLC, and elemental analysis, to verify identity, enantiomeric excess, and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent decomposition. Due to its hygroscopic and easily oxidized nature, the container should only be opened in a controlled, moisture-free environment.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity	≥ 99.0% ee
Rhodium Content	11.0 - 12.0 %
Solubility	Soluble in dichloromethane, acetone; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.