Description

Fmoc-D-Gln(Mtt)-Oh is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, enantiomerically pure building blocks to construct complex peptides and peptidomimetics. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CROs/CMOs engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the controlled, sequential assembly of custom peptide sequences.
• Pharmaceutical Research: For the discovery and development of novel peptide-based therapeutics, including hormone analogs and receptor-targeting drugs.
• Bioconjugation: Used to introduce glutamine residues with orthogonal protecting groups for site-specific labeling or modification of biomolecules.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to identify bioactive peptide leads.
• Peptidomimetic Design: Enables the incorporation of non-natural or modified glutamine analogs into synthetic peptide chains to enhance stability or activity.
• Academic Research: Employed in biochemical and structural biology studies to probe protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	Fmoc-D-Gln(Mtt)-Oh
CAS No.	200638-37-5
Molecular Formula	C₄₀H₄₂N₂O₆
Molecular Weight	646.78 g/mol
Synonyms	Fmoc-D-glutamine(Mtt)-OH; N-α-Fmoc-N-γ-(4-methyltrityl)-D-glutamine; Fmoc-D-Gln(Mtt)-OH; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[[4-methylphenyl]-diphenylmethyl]amino]-5-oxopentanoic acid; N-α-(9-Fluorenylmethyloxycarbonyl)-N-γ-(4-methyltrityl)-D-glutamine; Fmoc-D-Glutamine(Mtt)-OH; Fmoc-D-Gln(Mtt)-OH CAS 200638-37-5
EINECS	Contact for details

Quality Control

Our Fmoc-D-Gln(Mtt)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.