Description

Z-D-Gln(Trt)-Oh is a protected glutamine derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity, sequence-specific amino acid precursors to construct complex peptides and peptidomimetics. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical protected amino acid for the sequential assembly of peptide chains on resin.
• Therapeutic Peptide Production: Used in the research and GMP manufacturing of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic & Protein Engineering: Serves as a precursor for creating modified peptides and engineered proteins with enhanced stability or biological activity.
• Bioconjugation & Labeling: The reactive carboxyl group allows for site-specific conjugation to other molecules, carriers, or fluorescent labels.
• Academic & Industrial Research: A fundamental reagent in laboratories for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Z-D-Gln(Trt)-Oh
CAS No.	200625-96-3
Molecular Formula	C32H30N2O5
Molecular Weight	522.59 g/mol
Synonyms	Nα-Z-D-Glutamine Trityl Amide; Nα-Carbobenzoxy-D-glutamine tritylamide; Z-D-Glutamine(Trt)-OH; Z-D-Gln(Trt)-OH; Fmoc-D-Gln(Trt)-OH precursor; (2R)-5-[(Tritylamino)-4-oxo]-2-{[(benzyloxy)carbonyl]amino}pentanoic acid; D-Glutamine, N2-[(phenylmethoxy)carbonyl]-, N5-trityl-; Boc-D-Gln(Trt)-OH analog
EINECS	Contact for details

Quality Control

Our Z-D-Gln(Trt)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research-grade and GMP-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.