Description

H-D-Gln-Nh2 Hcl is a protected amino acid derivative, specifically the hydrochloride salt of H-D-Glutamine amide. This high-purity building block is critical for the synthesis of complex peptides and bioactive compounds where precise stereochemistry and side-chain protection are required. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, drug discovery, and the development of novel therapeutic agents.

Application

• Peptide Synthesis: As a key chiral building block in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: For the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used in the preparation of peptide-protein conjugates for diagnostic and therapeutic applications.
• Biochemical Research: As a substrate or inhibitor in enzymatic studies and proteomics research.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening and drug discovery platforms.

Basic Information

Product Name	H-D-Gln-Nh2 Hcl
CAS No.	200624-59-5
Molecular Formula	C5H12N3O2 • HCl
Molecular Weight	197.63 g/mol (Free base: 161.17)
Synonyms	H-D-Glutamine amide hydrochloride; D-Glutamine amide hydrochloride; (R)-2-Amino-4-carbamoylbutanamide hydrochloride; Fmoc-D-Gln(Trt)-NH2 precursor; D-Gln-NH2 • HCl; Boc-D-Gln-NH2 • HCl (deprotected form); Protected D-glutamine derivative
EINECS	Contact for details

Quality Control

Our H-D-Gln-Nh2 Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation by IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.