Description

Boc-D-Glu(Otbu)-Onp is a protected amino acid derivative, specifically an active ester of Boc-D-glutamic acid γ-tert-butyl ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of D-glutamic acid into peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates, where precise stereochemistry and side-chain protection are essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it is a key reagent for the efficient coupling of D-glutamic acid with tert-butyl side-chain protection into growing peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including potential therapeutics for metabolic, oncological, and neurological targets.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and research applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic Research: Fundamental studies in organic chemistry, peptide science, and asymmetric synthesis.

Basic Information

Product Name	Boc-D-Glu(Otbu)-Onp
CAS No.	200397-60-0
Molecular Formula	C₂₀H₂₈N₂O₈
Molecular Weight	424.45 g/mol
Synonyms	Boc-D-Glu(OtBu)-ONp; N-(tert-Butoxycarbonyl)-D-glutamic acid 5-tert-butyl ester 1-(4-nitrophenyl) ester; D-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(1,1-dimethylethyl) ester, 1-(4-nitrophenyl) ester; Boc-D-Glutamic acid γ-tert-butyl ester p-nitrophenyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-5-((tert-butoxy)carbonyl)pentanoic acid 4-nitrophenyl ester; Boc-D-Glu(OtBu)-OPNP; Active ester of Boc-D-Glutamic acid γ-tert-butyl ester
EINECS	Contact for details

Quality Control

Our Boc-D-Glu(Otbu)-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring the material meets the stringent specifications required for advanced peptide synthesis and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Chiral Purity	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.