Description

Fmoc-Cys(2-Hydroxyethyl)-Oh is a protected cysteine derivative featuring a 2-hydroxyethyl thioether side chain and an Fmoc-protected α-amino group. This specialized amino acid building block is critical for the solid-phase peptide synthesis (SPPS) of peptides containing modified cysteine residues, enabling the introduction of unique functional handles or hydrophilic properties into peptide sequences. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science who require precise control over peptide structure and side-chain chemistry to develop novel therapeutics and biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated synthesis of complex peptides.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation & Linker Chemistry: The hydroxyl group on the side chain provides a site for further chemical modification, cross-linking, or attachment to surfaces, polymers, or other biomolecules.
• Structure-Activity Relationship (SAR) Studies: Enables the exploration of how cysteine side-chain modifications affect peptide bioactivity and stability.
• Labeled Peptide Production: Serves as a precursor for synthesizing peptides with fluorescent or other reporter tags attached via the side-chain hydroxyl.
• Materials Science: Used to create peptide-based hydrogels, nanomaterials, or surface coatings where the hydrophilic hydroxyethyl side chain modulates material properties.

Basic Information

Product Name	Fmoc-Cys(2-Hydroxyethyl)-Oh
CAS No.	200354-35-4
Molecular Formula	C₂₂H₂₅NO₅S
Molecular Weight	415.50 g/mol
Synonyms	Fmoc-S-(2-Hydroxyethyl)-L-cysteine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(2-hydroxyethyl)-L-cysteine; Fmoc-Cys(2-Hydroxyethyl)-OH; Fmoc-L-Cys(2-Hydroxyethyl)-OH; Nα-Fmoc-S-(2-hydroxyethyl)-L-cysteine; Fmoc-Cys(SEtOH)-OH; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(2-hydroxyethylsulfanyl)propanoic acid; Fmoc-Cysteine(2-hydroxyethyl) free acid
EINECS	Contact for details

Quality Control

Our Fmoc-Cys(2-Hydroxyethyl)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive); containers should be allowed to reach room temperature before opening to prevent condensation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Assay (Titration)	97.0% - 102.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.