Description

Z-n-Me-Asp(Otbu)-Oh·Dcha is a protected amino acid derivative, specifically an N-methylated aspartic acid with tert-butyl ester protection and a dicyclohexylamine (DCHA) salt form. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering enhanced stability and controlled reactivity during solid-phase and solution-phase coupling. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptide analogs.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used as a protected amino acid residue in both solid-phase peptide synthesis (SPPS) and solution-phase methodologies to construct specific peptide sequences.
• Protease Inhibitor Development: Serves as a precursor in the synthesis of compounds designed to inhibit specific enzymes like aspartic proteases.
• Biochemical Research: Employed in academic and industrial labs for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new lead compounds with therapeutic potential.

Basic Information

Product Name	Z-n-Me-Asp(Otbu)-Oh·Dcha
CAS No.	200341-08-8
Molecular Formula	C27H42N2O6
Molecular Weight	490.64 g/mol
Synonyms	N-(Benzyloxycarbonyl)-N-methyl-L-aspartic acid 4-tert-butyl ester dicyclohexylamine salt; Z-N-Me-Asp(OtBu)-OH·DCHA; N-CBZ-N-methyl-L-aspartic acid β-tert-butyl ester DCHA salt; (2S)-4-tert-Butyl 1-(benzyloxycarbonyl(methyl)amino)-1-oxobutan-2-yl hydrogen aspartate dicyclohexylamine; Z-N-Me-L-Asp(OtBu)-OH DCHA salt; Nα-Carbobenzoxy-Nα-methyl-L-aspartic acid 4-tert-butyl ester dicyclohexylammonium salt
EINECS	Contact for details

Quality Control

Our Z-n-Me-Asp(Otbu)-Oh·Dcha is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.