Description

Z-D-Asn(Mtt)-Oh is a protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in enabling the controlled assembly of complex peptides and proteins, particularly where the orthogonal protection of the asparagine side chain is required. Pharmaceutical researchers, biotech companies, and CROs specializing in peptide-based drug discovery and development are the primary users of this high-purity intermediate.

Application

• Peptide Drug Synthesis: A key intermediate for constructing therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Research Peptide Production: Used in academic and industrial R&D for synthesizing custom peptides for structure-activity relationship (SAR) studies.
• Combinatorial Chemistry Libraries: Serves as a building block for creating diverse peptide libraries used in high-throughput screening.
• GPCR Ligand Development: Integral to the synthesis of peptide ligands for G-protein-coupled receptors, a major drug target class.
• Antibiotic Peptide Analogues: Employed in the research and development of novel antimicrobial peptide analogues.
• Diagnostic Reagent Manufacturing: Used in the production of peptide components for in-vitro diagnostic assays and kits.

Basic Information

Product Name	Z-D-Asn(Mtt)-Oh
CAS No.	200276-64-8
Molecular Formula	C31H32N2O7
Molecular Weight	544.60 g/mol
Synonyms	Nα-Benzyloxycarbonyl-Nω-(4-methyltrityl)-D-asparagine; Z-D-Asn(Mtt)-OH; Z-D-Asparagine(Mtt)-OH; Nα-Cbz-Nω-Mtt-D-asparagine; Benzyl N-[(2R)-1-[[(4-methylphenyl)-diphenylmethyl]amino]-1-oxo-3-[(phenylmethoxy)carbonylamino]propan-2-yl]carbamate; Fmoc-D-Asn(Mtt)-OH precursor; D-Asn(Mtt) protected amino acid; Boc-D-Asn(Mtt)-OH analogue
EINECS	Contact for details

Quality Control

Our Z-D-Asn(Mtt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.