Description

n-γ-Trityl-D-Asparagine is a protected derivative of the amino acid D-asparagine, featuring a trityl (triphenylmethyl) group on the γ-nitrogen. This compound is a critical chiral building block and protecting group reagent in the synthesis of complex peptides and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced organic synthesis, process development, and the production of peptide-based therapeutics.

Application

• Peptide Synthesis: Serves as a key protected intermediate for the solid-phase and solution-phase synthesis of peptides containing D-asparagine, ensuring optical purity and preventing side reactions.
• Pharmaceutical Intermediates: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and neurology drug candidates.
• Bioconjugation Chemistry: Acts as a specialized linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or drug delivery systems.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in the stereoselective construction of complex natural products and non-natural amino acid derivatives.
• Biochemical Research: Utilized in studies of enzyme mechanisms, receptor-ligand interactions, and the structure-activity relationships (SAR) of peptides.
• Process Chemistry: Applied in the scale-up and optimization of manufacturing routes for peptide drugs, providing a reliable and high-purity raw material.

Basic Information

Product Name	n-γ-Trityl-D-Asparagine
CAS No.	200192-49-0
Molecular Formula	C25H24N2O3
Molecular Weight	400.47 g/mol
Synonyms	D-Asparagine, Nγ-trityl-; Nγ-Trityl-D-asparagine; (R)-2-Amino-3-((tritylamino)carbonyl)propanoic acid; Nγ-Triphenylmethyl-D-asparagine; Fmoc-D-Asn(Trt)-OH (related protected form); D-Asn(Trt)-OH; Nγ-(Triphenylmethyl)-D-asparagine; γ-Trityl-D-asparagine
EINECS	Contact for details

Quality Control

Our n-γ-Trityl-D-Asparagine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.