Description

Z-D-Arg(Z)2-Osu CAS NO 200191-86-2 is a protected dipeptide derivative, specifically an N-hydroxysuccinimide (Osu) ester of Z-D-Arg(Z)2, designed for efficient peptide synthesis. This compound is a critical building block for the controlled introduction of the D-arginine moiety into peptide chains, enabling the creation of complex, biologically active molecules with enhanced stability and specificity. It is essential for researchers and manufacturers in pharmaceutical development, proteomics research, and the production of therapeutic peptides and diagnostic reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient, racemization-free coupling of D-arginine in automated and manual peptide assembly.
• Solution-Phase Peptide Synthesis: For constructing peptide fragments and small peptides in solution, offering flexibility in synthetic strategy.
• Bioconjugation: Used to label proteins, antibodies, or other biomolecules with arginine-containing peptide tags or motifs.
• Pharmaceutical Intermediate: A key precursor in the synthesis of peptide-based drug candidates, including enzyme inhibitors and receptor agonists/antagonists.
• Research & Development: For studying structure-activity relationships (SAR) and developing novel peptide analogs in academic and industrial R&D labs.
• Production of Custom Peptides: Enables contract manufacturing organizations (CMOs) to produce high-purity, sequence-specific peptides for clients.

Basic Information

Product Name	Z-D-Arg(Z)2-Osu
CAS No.	200191-86-2
Molecular Formula	C31H40N6O9
Molecular Weight	640.69 g/mol
Synonyms	Nα,Nω-Bis(benzyloxycarbonyl)-D-arginine N-hydroxysuccinimide ester; Z-D-Arg(Z)-OSu; H-D-Arg(Z2)-OSu; Nα-Carbobenzoxy-Nω-carbobenzoxy-D-arginine N-succinimidyl ester; Nα,Nω-Di-Z-D-arginine succinimidyl ester; Boc-D-Arg(Z)2-OSu (common naming variant); D-Arg(Z2)-OSu
EINECS	Contact for details

Quality Control

Our Z-D-Arg(Z)2-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can supply material compliant with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.