Description

Boc-Arg(Pmc)-Oh CAS NO 200125-12-8 is a protected derivative of the amino acid L-Arginine, featuring tert-butoxycarbonyl (Boc) and 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pmc) protecting groups. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the sequential construction of peptide chains.
• Pharmaceutical Research & Development: Used as a crucial intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Protein Engineering: Serves as a modified arginine residue for introducing specific functionalities or labels into peptides and proteins.
• Biochemical Reagent Production: Employed in the manufacture of high-purity substrates, inhibitors, and standards for enzymatic and proteomic studies.
• Cosmeceutical Peptide Synthesis: Used in the development of bioactive peptides for advanced skincare and cosmetic formulations.
• Academic & Institutional Research: A fundamental reagent for laboratories studying peptide chemistry, structure-activity relationships, and molecular biology.

Basic Information

Product Name	Boc-Arg(Pmc)-Oh
CAS No.	200125-12-8
Molecular Formula	C27H46N4O7S
Molecular Weight	570.75 g/mol
Synonyms	Nα-Boc-NG-(Pmc)-L-arginine; Boc-L-arginine(Pmc)-OH; (2S)-5-[[(2,2,5,7,8-Pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]amino]-2-[[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoic acid; Nα-tert-Butoxycarbonyl-Nω-pentamethylchroman-6-sulfonyl-L-arginine; Boc-Arg(Pmc)-OH; Boc-Arg(Pmc); BOC-L-ARG(PMC)-OH; tert-Butyloxycarbonyl-arginine(pentamethylchroman-6-sulfonyl)
EINECS	Contact for details

Quality Control

Our Boc-Arg(Pmc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.