Description

H-γ-Glu-Ala-Gly-PNA is a specialized synthetic peptide derivative containing a para-nitroanilide (PNA) chromogenic group. This compound serves as a critical chromogenic substrate for the detection and kinetic analysis of specific proteolytic enzymes, particularly γ-glutamyl transpeptidase (GGT) and related peptidases. It is an essential research-grade biochemical for pharmaceutical R&D, diagnostic assay development, and enzymology studies, enabling precise measurement of enzyme activity. The product is supplied under the CAS registry number 200003-11-8.

Application

• Enzyme Activity Assays: Primary substrate for the spectrophotometric determination of γ-glutamyl transpeptidase (GGT) activity in research and diagnostic applications.
• Diagnostic Reagent Development: Key component in the formulation of clinical chemistry reagents for liver function tests and other diagnostic panels.
• Pharmaceutical Research: Used in high-throughput screening (HTS) to identify and characterize inhibitors of GGT for potential therapeutic agents.
• Biochemical Research: A tool for studying enzyme kinetics, specificity, and the biochemical pathways involving γ-glutamyl cycle enzymes.
• Quality Control in Biomanufacturing: Employed in QC labs to monitor protease activity during biopharmaceutical production processes.

Basic Information

Product Name	H-γ-Glu-Ala-Gly-PNA
CAS No.	200003-11-8
Molecular Formula	C18H24N6O8
Molecular Weight	452.42 g/mol
Synonyms	L-γ-Glutamyl-L-alanylglycine 4-nitroanilide; γ-Glu-Ala-Gly-pNA; GGT Substrate; γ-Glutamyltransferase Substrate; N-(L-γ-Glutamyl)-L-alanylglycine 4-nitroanilide; L-γ-Glutamyl-L-alanyl-glycine p-nitroanilide; H-γ-Glu-Ala-Gly-pNA
EINECS	Contact for details

Quality Control

Our H-γ-Glu-Ala-Gly-PNA is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and verification of chromogenic activity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure the material meets the stringent requirements for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Assay (Enzymatic)	≥ 95% of theoretical activity
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.