Description

n-Desmethyl Clomipramine Hydrochloride is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant clomipramine. This compound is of significant importance for research and development in neuropharmacology and for the synthesis of novel therapeutic agents. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of tricyclic antidepressant drugs and their derivatives.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and validation.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the metabolism and activity of clomipramine.
• Impurity Profiling: Serves as a specified impurity standard in quality control to ensure the purity and safety of clomipramine API.
• Biochemical Research: Utilized in studies investigating serotonin and norepinephrine reuptake inhibition mechanisms.
• Preclinical Development: Employed in the development and testing of new central nervous system (CNS) active compounds.

Basic Information

Product Name	n-Desmethyl Clomipramine Hydrochloride
CAS No.	29854-14-6
Molecular Formula	C₁₈H₂₂Cl₂N₂ • HCl
Molecular Weight	377.75 g/mol
Synonyms	Norclomipramine Hydrochloride; Desmethylclomipramine HCl; 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine Hydrochloride; Clomipramine Impurity C (Hydrochloride); Clomipramine Metabolite; 1-[3-(3-Chloro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylmethanamine Hydrochloride; Norclomipramine HCl; N-Desmethylclomipramine Hydrochloride
EINECS	Contact for details

Quality Control

Our n-Desmethyl Clomipramine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.