Description

H-Pro-Nme2 is a high-purity, specialized proline derivative with the CAS registry number 29802-22-0. This compound is a critical building block in advanced organic synthesis, valued for its role in modulating peptide structure and function. It is essential for research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on peptide-based therapeutics, prodrug development, and novel drug discovery platforms.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the synthesis of complex active pharmaceutical ingredients (APIs) and peptide drugs.
• Peptide Chemistry: Used to introduce modified proline residues into peptide chains to enhance stability, bioavailability, and biological activity.
• Bioconjugation: Acts as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other targeted therapies.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs exploring new chemical entities and structure-activity relationships (SAR).
• Prodrug Synthesis: Employed in designing prodrugs to improve the pharmacokinetic profile of therapeutic agents.
• Biochemical Research: Used in studies investigating enzyme inhibition, receptor binding, and other biochemical mechanisms.

Basic Information

Product Name	H-Pro-Nme2
CAS No.	29802-22-0
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	N,N-Dimethyl-L-prolinamide; L-Proline, N,N-dimethylamide; (S)-N,N-Dimethylpyrrolidine-2-carboxamide; H-Pro-N(Me)2; Pro-NMe2; Pro-N,N-dimethylamide; Dimethylprolinamide; 29802-22-0
EINECS	Contact for details

Quality Control

Every batch of H-Pro-Nme2 (CAS 29802-22-0) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with exacting customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.