Description

Phenylthiohydantoin Tryptophan (CAS No. 29635-97-0) is a specialized derivative of the amino acid tryptophan, formed by reaction with phenyl isothiocyanate. This compound is of significant value in analytical biochemistry and peptide research, primarily serving as a key intermediate or marker. It is essential for laboratories and manufacturers engaged in advanced protein sequencing, amino acid analysis, and the development of diagnostic reagents. The product's defined structure ensures reliability in sensitive analytical applications where precision is paramount.

Application

• Edman Degradation Sequencing: Acts as a critical derivative for identifying tryptophan residues during stepwise peptide and protein sequencing.
• Amino Acid Analysis (AAA): Used as a reference standard or derivative in chromatographic methods (HPLC, UPLC) for the precise quantification of tryptophan.
• Biochemical Research: Serves as a building block or analytical tool in studying protein structure, function, and metabolism.
• Pharmaceutical Development: Employed in the research and quality control of peptide-based therapeutics and APIs containing tryptophan.
• Diagnostic Reagent Manufacturing: Utilized in the production of kits and reagents for clinical diagnostics and life science research.
• Proteomics and Metabolomics: Functions as a standard in mass spectrometry and other advanced analytical platforms for biomarker discovery.

Basic Information

Product Name	Phenylthiohydantoin Tryptophan
CAS No.	29635-97-0
Molecular Formula	C₁₉H₁₇N₃O₂S
Molecular Weight	351.42 g/mol
Synonyms	PTH-Tryptophan; 3-[2-(Phenylamino)-1,3-dithioxo-5-imidazolidinyl]propanoic Acid; Phenylthiohydantoin Derivative of Tryptophan; Tryptophan Phenylthiohydantoin; PTH-Trp; (RS)-2-(Phenylamino)-5-(2-carboxyethyl)-4-imidazolidinedithione; Edman Degradation Product of Tryptophan
EINECS	Contact for details

Quality Control

Every batch of Phenylthiohydantoin Tryptophan is manufactured and tested under strict quality management systems. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via techniques such as HPLC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the stringent requirements for research and analytical applications, supporting compliance with relevant internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.