Description

N,N''-Diphthaloyl-L-Cystine is a specialized, high-purity chemical derivative of the amino acid L-cystine, where the amine groups are protected by phthaloyl groups. This compound is critically important as a key chiral building block and intermediate in the synthesis of complex peptides, pharmaceuticals, and bioactive molecules, ensuring stereochemical integrity. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial protected precursor in the multi-step synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the L-cystine moiety while preventing unwanted side reactions.
• Bioconjugation & Probe Development: Acts as a linker or functional handle for creating fluorescent probes, antibody-drug conjugates (ADCs), and other bioconjugates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in the synthesis of non-peptidic compounds requiring high enantiomeric purity.
• Biochemical Research: Utilized in studies of disulfide bond formation, protein folding, and redox biology due to its protected thiol groups.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	N,N''-Diphthaloyl-L-Cystine
CAS No.	29588-96-3
Molecular Formula	C20H14N2O8S2
Molecular Weight	466.46 g/mol
Synonyms	N,N'-Diphthaloyl-L-cystine; L-Cystine, N,N'-diphthaloyl-; Bis(N-phthaloyl)-L-cystine; (2R,2'R)-3,3'-Disulfanediylbis(2-(1,3-dioxoisoindolin-2-yl)propanoic acid); N,N'-Bis(phthaloyl)-L-cystine; Phthaloyl-L-cystine anhydride; DPC
EINECS	Contact for details

Quality Control

Our N,N''-Diphthaloyl-L-Cystine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.