Description

n-Trifluoroacetyl-Dl-tert-Leucine Benzyl Ester is a protected amino acid derivative, specifically a benzyl ester of N-trifluoroacetyl tert-leucine. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the preparation of peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially those containing sterically hindered amino acids like tert-leucine.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the tert-leucine residue.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, where the tert-leucine moiety is often critical for binding affinity and selectivity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic reactions and the synthesis of non-natural amino acids.
• Bioconjugation & Labeling: The reactive ester group can be utilized for bioconjugation strategies in chemical biology research.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	n-Trifluoroacetyl-Dl-tert-Leucine Benzyl Ester
CAS No.	29588-16-7
Molecular Formula	C15H18F3NO3
Molecular Weight	317.30 g/mol
Synonyms	N-(Trifluoroacetyl)-DL-tert-leucine benzyl ester; Benzyl 2-[(2,2,2-trifluoroacetyl)amino]-3,3-dimethylbutanoate; DL-N-Trifluoroacetyl-tert-leucine benzyl ester; N-TFA-DL-tert-Leucine-OBzl; 2-[(2,2,2-Trifluoroacetyl)amino]-3,3-dimethylbutanoic acid phenylmethyl ester; (RS)-N-Trifluoroacetyl-tert-leucine benzyl ester; Bzl-DL-Tle(Tfa)-OH; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl-Dl-tert-Leucine Benzyl Ester is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storage under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.