Description

Phenylthiohydantoin Glutamine (CAS NO 29588-05-4) is a specialized derivative of glutamine, a key amino acid, modified with a phenylthiohydantoin moiety. This compound is of significant value in biochemical research and analytical chemistry, particularly for peptide sequencing and amino acid analysis. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical service providers engaged in proteomics and advanced material science.

Application

• Peptide Sequencing: Used as a key reagent in the Edman degradation process for stepwise determination of amino acid sequences in peptides and proteins.
• Amino Acid Analysis: Serves as a derivative for the sensitive detection and quantification of glutamine residues in complex biological samples via HPLC or LC-MS.
• Biochemical Research: Employed in studies investigating protein structure, function, and post-translational modifications.
• Proteomics: A valuable tool in mass spectrometry-based proteomic workflows for protein identification and characterization.
• Pharmaceutical Development: Used in the research and quality control of peptide-based therapeutics and biologics.
• Reference Standard: Acts as a high-purity analytical standard for method validation and calibration in analytical laboratories.

Basic Information

Product Name	Phenylthiohydantoin Glutamine
CAS No.	29588-05-4
Molecular Formula	C14H15N3O3S
Molecular Weight	305.35 g/mol
Synonyms	PTH-Glutamine; 3-Phenyl-2-thiohydantoin glutamine derivative; Glutamine phenylthiohydantoin; L-Glutamine, N-(3-phenyl-2-thioxo-4-imidazolidinylidene)-; PTH-Gln; Edman degradation product of Glutamine; 2-Thiohydantoin, 3-phenyl-, glutamine derivative
EINECS	Contact for details

Quality Control

Our Phenylthiohydantoin Glutamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.