Description

L-Alanyl-L-Proline tert-Butyl Ester is a protected dipeptide building block of significant importance in synthetic organic and medicinal chemistry. This compound is specifically designed for use in solid-phase and solution-phase peptide synthesis (SPPS), where it serves as a key intermediate for constructing more complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and prodrugs. The tert-butyl ester group provides crucial protection for the carboxylic acid moiety, allowing for selective deprotection under mild acidic conditions during multi-step syntheses.

Application

• Pharmaceutical Intermediate: A critical building block in the research and development of new peptide-based active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the sequential assembly of custom peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: Employed in traditional coupling reactions for constructing specific dipeptide motifs or larger fragments.
• Prodrug Development: Serves as a precursor for creating prodrug forms of peptides, enhancing their bioavailability and stability.
• Biochemical Research: Utilized in studies investigating enzyme-substrate interactions, peptide stability, and structure-activity relationships (SAR).
• Peptidomimetic Design: Acts as a scaffold for designing and synthesizing non-peptide compounds that mimic the function of natural peptides.

Basic Information

Item	Detail
Product Name	L-Alanyl-L-Proline tert-Butyl Ester
CAS No.	29375-30-2
Molecular Formula	C₁₆H₂₈N₂O₄
Molecular Weight	312.41 g/mol
Synonyms	H-Ala-Pro-OtBu; Boc-Ala-Pro-OtBu (if N-terminal Boc-protected); L-Alanyl-L-proline 1,1-dimethylethyl ester; tert-Butyl L-alanyl-L-prolinate; Ala-Pro-OtBu; N-(tert-Butoxycarbonyl)alanylproline tert-butyl ester; Alanylproline tert-butyl ester; (2S)-1-[(2S)-2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-Alanyl-L-Proline tert-Butyl Ester is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the certificate of analysis. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.