Description

5,6,7,8-Tetrahydrofolic Acid is a reduced form of folic acid, serving as a key biochemical intermediate in one-carbon metabolism. This compound is critical for research and development in life sciences, particularly in studying enzymatic pathways and cellular processes. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic institutions focused on biochemistry and nutrition.

Application

• Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development and quality control in drug manufacturing.
• Biochemical Research: Essential for in-vitro studies of folate-dependent enzymes like dihydrofolate reductase (DHFR) and thymidylate synthase.
• Diagnostic Reagent Component: Incorporated into assay kits for the detection and quantification of folate and related metabolites in clinical samples.
• Nutritional Science Studies: Employed in research to understand the bioavailability and metabolic fate of reduced folate forms.
• Cell Culture Media Supplement: Used in specialized cell culture applications requiring defined folate sources.
• Enzyme Cofactor Studies: Acts as a cofactor or substrate in enzymatic reaction studies for mechanistic and kinetic analysis.

Basic Information

Product Name	5,6,7,8-Tetrahydrofolic Acid
CAS No.	29347-89-5
Molecular Formula	C19H23N7O6
Molecular Weight	445.43 g/mol
Synonyms	5,6,7,8-THFA; Tetrahydrofolate; 5,6,7,8-Tetrahydrofolate; 5,6,7,8-Tetrahydrofolic acid; H4 folate; 5,6,7,8-Tetrahydropteroyl-L-glutamic acid; (6S)-5,6,7,8-Tetrahydrofolic acid; (6S)-Tetrahydrofolate
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydrofolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to protect against moisture. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC/UV)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.