Description

(Dichloromethylene)Bisphosphonic Acid, Sodium Salt is a high-purity organophosphorus compound, also known as Clodronate Disodium. This compound is valued for its potent chelating and bone resorption inhibition properties, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by manufacturers in the pharmaceutical, biotechnology, and research sectors for developing osteoporosis treatments and as a key component in bone-targeting drug delivery systems.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of Clodronate Disodium, a bisphosphonate drug used to treat bone diseases like osteoporosis and Paget's disease.
• Bone Metabolism Research: Used in biochemical and pharmacological research to study osteoclast activity and bone resorption mechanisms.
• Chelating Agent: Employed in specialized chemical processes and formulations requiring strong calcium and metal ion sequestration.
• Veterinary Medicine: Component in developing treatments for skeletal disorders in animals.
• Analytical Chemistry: Serves as a reference standard in HPLC and other analytical methods for quality control of bisphosphonate APIs.
• Bioconjugation: Potential use in creating bone-targeting conjugates for diagnostic or therapeutic agents.

Basic Information

Product Name	(Dichloromethylene)Bisphosphonic Acid, Sodium Salt
CAS No.	29329-69-9
Molecular Formula	CH2Cl2Na2O6P2
Molecular Weight	288.86 g/mol
Synonyms	Clodronic Acid Disodium Salt; Dichloromethylene Diphosphonate Disodium; Clodronate Disodium; (Dichloromethylene)diphosphonic Acid Disodium Salt; Methylenechloride Diphosphonate Disodium; BM-06011; Disodium Clodronate; Cl2MDP-Na2
EINECS	249-552-7

Quality Control

Our (Dichloromethylene)Bisphosphonic Acid, Sodium Salt is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical intermediate use. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Chloride Content	Conforms
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
pH (5% solution)	4.0 - 6.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.