Description

2(1H)-Naphthalenone, 1-Fluoro-3,4,4A-α-,5,6,7,8,8A-Bta--Octahydro- (8Ci) is a fluorinated octahydronaphthalenone derivative, a specialized organic intermediate of significant interest in advanced chemical synthesis. Its value lies in its unique stereochemistry and the presence of a fluorine atom, which are critical for modulating the biological activity and physical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the fluorine atom enhances bioavailability and environmental stability.
• Material Science Research: Investigated as a precursor for specialty polymers and liquid crystals, leveraging its rigid, fused-ring structure.
• Catalyst Ligand Development: The specific stereocenters make it a candidate for developing novel chiral ligands used in asymmetric catalysis.
• Flavor & Fragrance Chemistry: Potential intermediate for creating complex, stereodefined odorant molecules.
• Academic & Contract Research: A valuable reagent for methodological studies in organic synthesis, especially fluorination and hydrogenation chemistry.

Basic Information

Product Name	2(1H)-Naphthalenone, 1-Fluoro-3,4,4A-α-,5,6,7,8,8A-Bta--Octahydro- (8Ci)
CAS No.	29293-34-3
Molecular Formula	C₁₀H₁₃FO
Molecular Weight	168.21 g/mol
Synonyms	1-Fluoro-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-one; 1-Fluoro-3,4,4a,5,6,7,8,8a-octahydro-2(1H)-naphthalenone; 1-Fluoro-octahydro-2-naphthalenone; 1-Fluoro-perhydro-2-naphthalenone; (1R,4aS,8aS)-1-Fluoro-3,4,4a,5,6,7,8,8a-octahydro-2H-naphthalen-2-one (stereoisomer); (1S,4aR,8aR)-1-Fluoro-3,4,4a,5,6,7,8,8a-octahydro-2H-naphthalen-2-one (stereoisomer); Fluorinated octahydronaphthalenone; Decahydro-1-fluoro-2-naphthalenone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using NMR (¹H, ¹³C, ¹⁹F), HPLC, GC, and chiral analysis to confirm identity, purity, and enantiomeric excess where applicable. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Purity (HPLC/GC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation (if chiral)	Provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.