Description

α-Bromo-4-Fluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant synthetic utility. Its core value lies in its bifunctional structure, featuring both a reactive α-bromo carbonyl group and a fluorinated phenyl ring, making it an essential intermediate for constructing complex molecules. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies.
• Peptidomimetics & Bio-conjugation: The bromoacetyl group is reactive towards nucleophiles, useful for creating peptide analogs or for bioconjugation strategies.
• Cross-Coupling Reactions: The aryl bromide moiety can participate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Chemical Research & Development: A valuable reagent for exploring new fluorination effects and reaction pathways in academic and industrial R&D settings.

Basic Information

Item	Detail
Product Name	α-Bromo-4-Fluorophenylacetic Acid
CAS No.	29270-33-5
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	2-Bromo-2-(4-fluorophenyl)acetic Acid; (4-Fluorophenyl)bromoacetic Acid; 4-Fluoro-α-bromophenylacetic Acid; α-Bromo-4-fluorobenzeneacetic Acid; p-Fluoro-α-bromophenylacetic Acid; Bromo(4-fluorophenyl)acetic Acid; NSC 403079; BRN 2208503
EINECS	Contact for details

Quality Control

Our α-Bromo-4-Fluorophenylacetic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.