Description

Boc-N'-Nitro-L-Homoarginine is a protected derivative of the non-proteinogenic amino acid homoarginine, featuring both a tert-butoxycarbonyl (Boc) protecting group and a nitro group on the guanidino moiety. This compound is a critical building block in peptide synthesis and medicinal chemistry research, offering precise control over the introduction of a modified arginine side chain. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for developing novel peptide-based therapeutics and biochemical probes.

Application

• Peptide Synthesis Intermediate: Serves as a key protected amino acid for solid-phase and solution-phase peptide synthesis (SPPS).
• Medicinal Chemistry Research: Used in the design and development of enzyme inhibitors, particularly those targeting nitric oxide synthase (NOS) and other arginine-processing enzymes.
• Biochemical Tool Development: Employed in the synthesis of labeled peptides and affinity tags for proteomics and protein interaction studies.
• Pharmaceutical Reference Standard: Acts as a high-purity standard for analytical method development and quality control in API manufacturing.
• Structure-Activity Relationship (SAR) Studies: Facilitates the exploration of peptide bioactivity by allowing systematic modification of the arginine homolog structure.

Basic Information

Product Name	Boc-N'-Nitro-L-Homoarginine
CAS No.	28968-64-1
Molecular Formula	C₁₂H₂₄N₆O₆
Molecular Weight	348.36 g/mol
Synonyms	N2-[(tert-Butoxy)carbonyl]-N5-nitro-L-homoarginine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-(nitroamino)hexanoic acid; Boc-HomoArg(NO2)-OH; Boc-NG-Nitro-L-homoarginine; tert-Butyl N-[(5S)-5-amino-6-(nitroamino)hexyl]carbamate; Nα-Boc-NG-Nitro-L-homoarginine; Fmoc-HomoArg(NO2)-OH (related Fmoc-protected variant); L-Homoarginine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-nitro-
EINECS	Contact for details

Quality Control

Our Boc-N'-Nitro-L-Homoarginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.