Description

N,n-Bis(Trifluoromethyl)-2-(Trimethylsilyl)Ethanamine is a specialized organofluorine and organosilicon compound that serves as a high-value building block in advanced synthetic chemistry. Its unique molecular structure, featuring both trifluoromethyl and trimethylsilyl protecting groups, makes it a critical reagent for introducing fluorinated motifs and enabling complex transformations. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise fluorination and silylation agents. Its properties facilitate the development of novel active ingredients and functional materials with enhanced stability and performance.

Application

• Pharmaceutical Intermediate: Used in the synthesis of fluorinated drug candidates, particularly for introducing metabolically stable CF3 groups to improve bioavailability and lipophilicity.
• Agrochemical Synthesis: Serves as a key precursor for creating advanced pesticides and herbicides with fluorine-containing active ingredients for increased efficacy and environmental persistence.
• Advanced Material Precursor: Employed in the production of specialty polymers, coatings, and electronic materials where fluorinated and silylated components impart specific chemical resistance, low surface energy, or dielectric properties.
• Organic Synthesis Reagent: Acts as a versatile reagent in organometallic chemistry and cross-coupling reactions, often used as a protecting group or a source of nucleophilic nitrogen in complex molecule assembly.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel ligands and catalysts for asymmetric synthesis and other catalytic processes.
• Fluorine Chemistry Research: A valuable compound for academic and industrial R&D focused on exploring new fluorination methodologies and the properties of fluoroorganic compounds.

Basic Information

Product Name	N,n-Bis(Trifluoromethyl)-2-(Trimethylsilyl)Ethanamine
CAS No.	28871-56-9
Molecular Formula	C8H15F6NSi
Molecular Weight	267.30 g/mol
Synonyms	2-(Trimethylsilyl)-N,N-bis(trifluoromethyl)ethanamine; N,N-Bis(trifluoromethyl)-2-(trimethylsilyl)ethylamine; Ethanamine, N,N-bis(trifluoromethyl)-2-(trimethylsilyl)-; (2-(Trimethylsilyl)ethyl)bis(trifluoromethyl)amine; TMS-Ethylamine-Bis(trifluoromethyl) Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our N,n-Bis(Trifluoromethyl)-2-(Trimethylsilyl)Ethanamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to verify identity, potency, and impurity profiles. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep away from heat, sparks, and open flame. The container must be kept tightly sealed when not in use to prevent moisture ingress and evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%
Density (at 20°C)	~1.25 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.