Description

n-Cbz-D-Leucine CAS NO 28862-79-5 is a protected amino acid derivative where the amine group of D-Leucine is safeguarded by a carboxybenzyl (Cbz) group. This compound is a critical chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing active pharmaceutical ingredients (APIs) and novel therapeutic peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and APIs.
• Peptide Research: Used in academic and industrial laboratories for constructing custom peptides with D-amino acids to enhance metabolic stability.
• Protease Inhibitor Development: Serves as a precursor in creating inhibitors that target specific enzymatic pathways.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex organic molecules requiring protected leucine moieties.
• Bioconjugation: Facilitates the site-specific modification of proteins and other biomolecules.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for drug discovery screening.

Basic Information

Product Name	n-Cbz-D-Leucine
CAS No.	28862-79-5
Molecular Formula	C₁₄H₁₉NO₄
Molecular Weight	265.31 g/mol
Synonyms	N-Carbobenzoxy-D-leucine; D-Leucine, N-[(phenylmethoxy)carbonyl]-; (R)-2-((Benzyloxycarbonyl)amino)-4-methylpentanoic acid; Z-D-Leu-OH; CBZ-D-Leucine; N-Benzyloxycarbonyl-D-leucine; Nα-Cbz-D-leucine; D-Leucine, N-carboxy-, N-benzyl ester
EINECS	Contact for details

Quality Control

Our n-Cbz-D-Leucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing specifications for identity, assay, and impurity profiles to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.