Description

Poly-L-Lysine Hydrochloride is a synthetic, cationic polypeptide derived from the amino acid L-lysine, widely recognized for its strong positive charge and cell-adhesive properties. This compound is essential for researchers and manufacturers requiring a reliable substrate for cell culture and bioprocessing applications. It is primarily utilized in the life sciences, biotechnology, and pharmaceutical industries to promote cell attachment to surfaces, enhancing experimental reproducibility and production yields.

Application

• Cell Culture Substrate: Coating agent for culture dishes, flasks, and slides to improve attachment and growth of adherent cell lines.
• Biomedical Research: Used in studies involving neuron culture, stem cell differentiation, and tissue engineering scaffolds.
• Diagnostic Assays: Facilitates the immobilization of biomolecules (e.g., DNA, proteins) on solid surfaces for microarray and biosensor development.
• Drug Delivery Systems: Investigated as a component in polymeric nanoparticles and coatings for controlled release formulations.
• Biocompatible Coatings: Applied to medical devices and implants to enhance biocompatibility and cellular integration.
• Virology & Vaccine Production: Supports the growth of certain virus types and cell-based vaccine manufacturing processes.

Basic Information

Product Name	Poly-L-Lysine Hydrochloride
CAS No.	28826-16-6
Molecular Formula	(C6H14N2O2·HCl)n
Molecular Weight	Varies by polymer chain length (n). Typically supplied in defined molecular weight ranges (e.g., 15-30 kDa, 70-150 kDa).
Synonyms	PLL; Poly(L-lysine) hydrochloride; Poly(L-lysine hydrobromide) related salt; L-Lysine homopolymer hydrochloride; (S)-Poly(lysine hydrochloride); Polylysine HCl; Cationic poly(amino acid); Cell-Tak™ (related commercial product); ε-Poly-L-lysine hydrochloride (for shorter chain polymers).
EINECS	Contact for details

Quality Control

Our Poly-L-Lysine Hydrochloride is produced under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for molecular weight distribution, purity, and biological performance. Certificates of Analysis (COA) detailing parameters such as assay, endotoxin levels, and sterility (where applicable) are provided to support research and GMP-compliant manufacturing. We adhere to relevant guidelines for biopharmaceutical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term stability, keep the container in a dry environment and allow it to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Molecular Weight Range	Specified per grade (e.g., 15-30 kDa, 70-150 kDa)
Assay (HPLC)	≥ 95.0%
pH (1% solution)	4.0 - 6.0
Loss on Drying	≤ 5.0 %
Endotoxin	< 1.0 EU/mg (for cell culture grade)
Biological Performance (Cell Attachment)	Pass

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.