Description

Poly-L-Ornithine Hydrobromide is a synthetic, positively charged polypeptide derived from the amino acid ornithine. This compound is valued for its strong cationic properties, which promote cell adhesion to various substrates in biological research and development. It is an essential reagent for researchers and manufacturers in the life sciences, biotechnology, and pharmaceutical sectors. The material is supplied as a high-purity solid to ensure consistent performance in sensitive applications.

Application

• Cell Culture Coating: Widely used as a coating agent to enhance the attachment and growth of various cell types, including neurons, epithelial cells, and stem cells, on cultureware surfaces.
• Biomaterial & Tissue Engineering: Serves as a functional layer to modify the surface properties of scaffolds and implants, improving biocompatibility and cellular integration.
• Gene Delivery & Transfection Research: Acts as a polycationic component in the formation of complexes with nucleic acids (DNA, siRNA) for non-viral transfection studies.
• Diagnostic Assay Development: Utilized to immobilize biomolecules (e.g., proteins, antibodies) on sensor chips or microplates for diagnostic and biosensing applications.
• Neurobiology Research: A standard substrate for culturing primary neurons and studying neurite outgrowth, synapse formation, and neurotoxicity.
• Pharmaceutical Formulation: Investigated for its potential use in drug delivery systems to improve the stability and cellular uptake of therapeutic agents.

Basic Information

Product Name	Poly-L-Ornithine Hydrobromide
CAS No.	27378-49-0
Molecular Formula	(C5H12N2O2 • HBr)n
Molecular Weight	Contact for details
Synonyms	Poly(ornithine hydrobromide); PLO; Poly-L-Ornithine HBr; L-Ornithine homopolymer hydrobromide; Poly(Orn)•HBr; NSC 14699; Polyornithine; Ornithine Polymer Hydrobromide
EINECS	Contact for details

Quality Control

Our Poly-L-Ornithine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and performance consistency suitable for research and in-vitro diagnostic use. Certificates of Analysis (COA) documenting key parameters such as molecular weight distribution, degree of polymerization, and endotoxin levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms
Assay (Nitrogen)	≥ 95.0%
Molecular Weight Range	15,000 - 70,000 Da (other ranges available)
Loss on Drying	≤ 5.0 %
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.