Description

Ethyl 2,2-Difluoropropionate is a versatile fluorinated ester building block, prized for its unique reactivity profile conferred by the difluoromethyl group. This compound is essential for introducing fluorine atoms into target molecules, a critical strategy for modulating the physicochemical and biological properties of advanced materials and pharmaceuticals. It serves as a key intermediate for researchers and manufacturers in the agrochemical, pharmaceutical, and specialty chemical sectors seeking to develop novel compounds with enhanced stability, bioavailability, or performance.

Application

• Pharmaceutical Intermediate: A crucial synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for incorporating difluoromethylene (-CF2-) units to improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where fluorine substitution can enhance efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a monomer or building block for creating specialty polymers, coatings, and liquid crystals with unique surface properties, chemical resistance, and optical characteristics.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and cross-coupling reactions to introduce ethyl propionate groups with adjacent fluorine atoms, enabling complex molecule construction.
• Life Science Research: Utilized in medicinal chemistry and drug discovery programs as a probe or intermediate for developing fluorinated analogs of bioactive molecules.

Basic Information

Product Name	Ethyl 2,2-Difluoropropionate
CAS No.	28781-85-3
Molecular Formula	C5H8F2O2
Molecular Weight	138.11 g/mol
Synonyms	2,2-Difluoropropionic Acid Ethyl Ester; Ethyl 2,2-Difluoropropanoate; Propanoic Acid, 2,2-Difluoro-, Ethyl Ester; Ethyl α,α-Difluoropropionate; EFDP
EINECS	Contact for details

Quality Control

Our Ethyl 2,2-Difluoropropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.