Description

7,12-Dimethylbenz(A)Anthracene-5,6-Dihydrodiol is a high-purity, synthetic dihydrodiol derivative of a polycyclic aromatic hydrocarbon (PAH). This compound is of significant value as a crucial biochemical research standard and metabolic intermediate in the study of carcinogenesis. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and toxicology testing facilities for mechanistic studies on metabolic activation pathways and DNA adduct formation.

Application

• Biochemical Research: Used as a key intermediate in studies investigating the metabolic activation pathways of polycyclic aromatic hydrocarbons (PAHs) to ultimate carcinogens.
• Toxicology & Carcinogenesis Studies: Serves as a critical standard for in vitro and in vivo research on the mechanisms of chemical carcinogenesis.
• Metabolite Standard: Employed as a reference standard in analytical methods (HPLC, LC-MS) for the identification and quantification of PAH metabolites in biological samples.
• Enzymology Studies: Utilized as a substrate for studying the activity and specificity of enzymes like cytochrome P450 and epoxide hydrolase.
• DNA Adduct Research: Applied in experiments to understand the formation and repair of DNA adducts, which are critical events in mutagenesis.
• Pharmaceutical Development: Used in early-stage research to model and screen for potential chemopreventive agents that block metabolic activation.

Basic Information

Product Name	7,12-Dimethylbenz(A)Anthracene-5,6-Dihydrodiol
CAS No.	28622-94-8
Molecular Formula	C20H18O2
Molecular Weight	290.36 g/mol
Synonyms	DMBA-5,6-dihydrodiol; 7,12-DMBA-5,6-dihydrodiol; 5,6-Dihydro-7,12-dimethylbenz[a]anthracene-5,6-diol; Benz[a]anthracene-5,6-diol, 7,12-dimethyl-; (±)-7,12-Dimethylbenz[a]anthracene-5,6-dihydrodiol; 7,12-Dimethylbenz[a]anthracene-5,6-diol; 5,6-Dihydroxy-5,6-dihydro-7,12-dimethylbenz[a]anthracene
EINECS	Contact for details

Quality Control

Our 7,12-Dimethylbenz(A)Anthracene-5,6-Dihydrodiol is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. All products undergo rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with each shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake and condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.