Description

(S)-Hydroxyphenylacetonitrile is a high-value chiral intermediate, specifically the (S)-enantiomer of mandelonitrile. This compound matters for its role as a crucial building block in the synthesis of optically active pharmaceuticals and fine chemicals. Industries that need it include pharmaceutical R&D, agrochemical manufacturing, and specialty chemical production for creating enantiomerically pure products. Its defined stereochemistry ensures consistent performance in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of adrenergic drugs, β-blockers, and other active pharmaceutical ingredients (APIs) requiring the (S)-configuration.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides and pesticides where biological activity is stereospecific.
• Fine Chemical Building Block: Serves as a starting material for complex chiral molecules in perfumery, flavor, and advanced material research.
• Asymmetric Catalysis Research: Employed as a standard substrate or ligand precursor in the development and testing of new chiral catalysts.
• Biocatalyst Substrate: Used in enzymatic resolution studies and biotransformation processes to produce high-value chiral alcohols or acids.

Basic Information

Product Name	(S)-Hydroxyphenylacetonitrile
CAS No.	28549-12-4
Molecular Formula	C8H7NO
Molecular Weight	133.15 g/mol
Synonyms	(S)-(-)-Mandelonitrile; (S)-2-Hydroxy-2-phenylacetonitrile; (S)-α-Hydroxybenzeneacetonitrile; L-(-)-Mandelonitrile; (S)-Phenylglycolonitrile; (S)-Cyanohydrin of benzaldehyde; (S)-Benzaldehyde cyanohydrin; (S)-Hydroxy(phenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our (S)-Hydroxyphenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.