Description

Methyl 2-Chlorotetrafluoropropionate is a specialized fluorinated ester compound. It serves as a critical building block and intermediate in advanced chemical synthesis, valued for its unique reactivity profile imparted by the chlorine and fluorine substituents. This high-purity intermediate is essential for manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs) and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides where fluorine incorporation improves efficacy and environmental profile.
• Fluorinated Polymer & Material Science: Acts as a monomer or modifier in the synthesis of specialty polymers, coatings, and surfactants with oil, water, and stain resistance.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and coupling reactions to introduce the 2-chlorotetrafluoropropionate moiety into complex molecular architectures.
• Liquid Crystal & Electronic Chemicals: Potential intermediate in the manufacture of fluorinated liquid crystals and dielectric fluids for the electronics industry.

Basic Information

Product Name	Methyl 2-Chlorotetrafluoropropionate
CAS No.	28509-44-6
Molecular Formula	C4H3ClF4O2
Molecular Weight	194.51 g/mol
Synonyms	Methyl 2-chloro-1,1,2,3,3,3-hexafluoropropionate; 2-Chloro-1,1,2,3,3,3-hexafluoropropyl methyl ester; Methyl 2-chloro-3,3,3-trifluoro-2-(trifluoromethyl)propanoate; 2-Chlorotetrafluoropropionic Acid Methyl Ester; Methyl α-Chlorohexafluoroisobutyrate; HCFO-1233xf Methyl Ester; Propanoic acid, 2-chloro-3,3,3-trifluoro-2-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Chlorotetrafluoropropionate is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment to guarantee batch-to-batch consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and fluorides. Due to its highly volatile nature, ensure containers are kept tightly sealed. Recommended storage temperature is 2-8°C for extended stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	1.50 - 1.55 g/mL
Refractive Index (n20D)	1.320 - 1.340

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.