Description

1-Fluoro-3-(Methoxymethyl)Benzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the combination of a reactive benzylic methoxymethyl group and a fluorine substituent, enabling precise molecular modifications. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic motifs which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom and the ether linkage contribute to biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Research: Acts as a building block for fluorinated cores in electronic and photonic materials, influencing dielectric anisotropy and emission properties.
• Organic Ligand Preparation: Employed in the synthesis of specialized ligands for catalysis, where the methoxymethyl group can be further functionalized or serve as a directing/protecting group.
• Cross-Coupling Reactions: Functions as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl and complex aromatic systems.
• Fluorine Chemistry Studies: Utilized in academic and industrial research to study the electronic effects of fluorine substitution adjacent to reactive sites on an aromatic ring.

Basic Information

Product Name	1-Fluoro-3-(Methoxymethyl)Benzene
CAS No.	28490-57-5
Molecular Formula	C8H9FO
Molecular Weight	140.16 g/mol
Synonyms	3-(Methoxymethyl)fluorobenzene; m-Fluorobenzyl methyl ether; 1-Fluoro-3-methoxymethylbenzene; (3-Fluorophenyl)methoxymethane; 3-Fluorobenzyl methyl ether; 28490-57-5; Fluorobenzene, 1-(methoxymethyl)-3-
EINECS	Contact for details

Quality Control

Our 1-Fluoro-3-(Methoxymethyl)Benzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing including GC, HPLC, and NMR to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.