Description

Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-L-Alanyl-, Methyl Ester is a protected amino acid derivative, specifically a Boc-L-Ala-Gly-OMe dipeptide building block, essential for advanced organic synthesis. This compound matters because it provides a precisely controlled reactive handle for constructing complex peptides and peptidomimetics with high stereochemical fidelity. Pharmaceutical researchers and fine chemical manufacturers need it for the development of active pharmaceutical ingredients (APIs), peptide-based therapeutics, and novel biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of custom peptides in drug discovery and research.
• Solution-Phase Peptide Coupling: Used in the synthesis of longer peptide chains or cyclic peptides where solution methods are preferred.
• Pharmaceutical Intermediate: Serves as a critical building block in the production of peptide-based Active Pharmaceutical Ingredients (APIs) and prodrugs.
• Bioconjugation & Probe Development: Facilitates the site-specific labeling of proteins or the creation of fluorescent or affinity tags for biochemical studies.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Used in universities and research institutes for studying peptide structure, function, and metabolism.

Basic Information

Product Name	Glycine, n-[(1,1-Dimethylethoxy)Carbonyl]-L-Alanyl-, Methyl Ester
CAS No.	28369-58-6
Molecular Formula	C11H20N2O5
Molecular Weight	260.29 g/mol
Synonyms	Boc-L-Ala-Gly-OMe; Boc-L-Alanyl-Glycine Methyl Ester; (tert-Butoxycarbonyl)-L-alanylglycine Methyl Ester; N-(tert-Butoxycarbonyl)-L-alanylglycine Methyl Ester; Methyl N-[(tert-butoxy)carbonyl]-L-alanylglycinate; Boc-Ala-Gly-OMe; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, 2-[(methoxycarbonyl)amino]ethyl ester; N-Boc-L-alanylglycine methyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Ala-Gly-OMe is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles as determined by advanced analytical techniques like HPLC and NMR. We adhere to cGMP principles where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.