Description

(1S,3S)-3-Acetyl-2,2-Dimethylcyclobutane Acetonitrile is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its rigid cyclobutane scaffold and functional handles make it a valuable precursor for constructing complex molecular architectures with precise spatial orientation. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates requiring a defined stereochemistry.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to introduce the cyclobutane moiety into target molecules with high enantiomeric excess.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and fragment-based drug discovery due to its constrained, three-dimensional structure.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, or insecticides where the cyclobutane ring can influence biological activity and stability.
• Material Science Precursor: Acts as a specialty monomer or cross-linking agent in the development of advanced polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new chemical spaces in high-throughput screening libraries.

Basic Information

Product Name	(1S,3S)-3-Acetyl-2,2-Dimethylcyclobutane Acetonitrile
CAS No.	28353-00-6
Molecular Formula	C10H15NO
Molecular Weight	165.23 g/mol
Synonyms	(1S,3S)-3-Acetyl-2,2-dimethylcyclobutanecarbonitrile; 3-Acetyl-2,2-dimethylcyclobutanecarbonitrile; (1S-cis)-3-Acetyl-2,2-dimethylcyclobutanecarbonitrile; 2,2-Dimethyl-3-acetylcyclobutanecarbonitrile; (1S,3S)-rel-3-Acetyl-2,2-dimethylcyclobutanecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of (1S,3S)-3-Acetyl-2,2-Dimethylcyclobutane Acetonitrile is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, typically including chiral HPLC analysis to confirm enantiomeric excess. Certificates of Analysis (COA) detailing all relevant specifications are available for each lot upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.